Reference Tissue–Based Kinetic Evaluation of 18F-AV-1451 for Tau Imaging
نویسندگان
چکیده
منابع مشابه
18F-AV-1451 tau PET imaging correlates strongly with tau neuropathology in MAPT mutation carriers
Tau positron emission tomography ligands provide the novel possibility to image tau pathology in vivo However, little is known about how in vivo brain uptake of tau positron emission tomography ligands relates to tau aggregates observed post-mortem. We performed tau positron emission tomography imaging with (18)F-AV-1451 in three patients harbouring a p.R406W mutation in the MAPT gene, encoding...
متن کاملPharmacokinetic Evaluation of the Tau PET Radiotracer 18F-T807 (18F-AV-1451) in Human Subjects.
18F-T807 is a PET radiotracer developed for imaging tau protein aggregates, which are implicated in neurologic disorders including Alzheimer disease and traumatic brain injury (TBI). The current study characterizes 18F-T807 pharmacokinetics in human subjects using dynamic PET imaging and metabolite-corrected arterial input functions. Methods: Nine subjects (4 controls, 3 with a history of TBI, ...
متن کاملComparing 18F-AV-1451 with CSF t-tau and p-tau for diagnosis of Alzheimer disease
OBJECTIVE To compare PET imaging of tau pathology with CSF measurements (total tau [t-tau] and phosphorylated tau [p-tau]) in terms of diagnostic performance for Alzheimer disease (AD). METHODS We compared t-tau and p-tau and 18F-AV-1451 in 30 controls, 14 patients with prodromal AD, and 39 patients with Alzheimer dementia, recruited from the Swedish BioFINDER study. All patients with AD (pro...
متن کاملAn autoradiographic evaluation of AV-1451 Tau PET in dementia
BACKGROUND It is essential to determine the specificity of AV-1451 PET for tau in brain imaging by using pathological comparisons. We performed autoradiography in autopsy-confirmed Alzheimer disease and other neurodegenerative disorders to evaluate the specificity of AV-1451 binding for tau aggregates. METHODS Tissue samples were selected that had a variety of dementia-related neuropathologie...
متن کامل18F‐AV‐1451 and CSF T‐tau and P‐tau as biomarkers in Alzheimer's disease
To elucidate the relationship between cerebrospinal fluid (CSF) total-tau (T-tau) and phosphorylated tau (P-tau) with the tau PET ligand 18F-AV-1451 in Alzheimer's disease (AD), we examined 30 cognitively healthy elderly (15 with preclinical AD), 14 prodromal AD, and 39 AD dementia patients. CSF T-tau and P-tau were highly correlated (R = 0.92, P < 0.001), but they were only moderately associat...
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ژورنال
عنوان ژورنال: Journal of Nuclear Medicine
سال: 2016
ISSN: 0161-5505,2159-662X
DOI: 10.2967/jnumed.116.175273